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血液干细胞研究平台

发布时间:2015-01-23 【字号: 浏览次数:
        干细胞研究平台是7022至尊国际至尊享受建立在相关研究成果基础上于2011年新成立的研究中心,主要从事人多能干细胞向功能成熟造血细胞诱导分化研究和人外周血/脐血重编程为诱导性多潜能干细胞以及相关疾病模型的研究。经过多年的研究积累,已掌握了将人多能干细胞与造血Niche基质细胞共培养获得大量造血干/祖细胞的方法,并能将人类多能干细胞来源的造血干/祖细胞诱导分化为功能成熟血细胞(红细胞、嗜酸性粒细胞、巨噬细胞、肥大细胞等),在这些成熟诱导方法的基础上探索全人源培养体系以及造血相关基因和小分子物质对造血分化的调控机制研究。平台研究资源丰富,在中国首批批准建设的7家脐带血干细胞库之一——四川省脐带造血干细胞库的丰富的干细胞资源上,目前已建立高效地从少量的人外周血/脐血重编程为诱导性多能干细胞的方法。 近年来先后承担“973”课题、国家自然科学基金面上项目等国家科研项目。分别与中国医学科学院天津血研所、基础医学研究所、浙江大学等科研院所合作,并和四川新生命干细胞公司以及中科善庆医学管理有限责任公司共建联合实验室从事人多能干细胞向临床应用研究。实验室现有科技人员16人,其中高级专业技术职称人员2人,硕士以上学历人员12人。近年来先后在国内外核心学术期刊发表论文26篇。平台主要从事高效地将人多能干细胞向成熟血液细胞诱导分化研究,人外周血/脐血高效重编程为诱导性多能干细胞以及相关疾病模型的研究;探索运用全人源培养方法从人多能干细胞产生造血干祖细胞;同时探索人类早期造血相关基因以及小分子物质对造血分化的调控机制。
The Center for Stem Cell Research & Application is a newly established one in 2011.The center mainly focus on uncovering mechanisms controlling human pluripotent stem cell (hPSCs, including hESC and hiPSCs) to differentiate into functionally mature hematopoietic cells and exploring the possibility of clinical applications. We also develop methods for efficiently reprogramming human peripheral / umbilical cord blood cells into hiPSCs. We are now fucusing on the following research:1) hPSC-derived hematopoietic stem / progenitor cells. 2)Molecular control of early human hematopoiesis by using hPSC as the model. 3) hPSC-derived erythrocytes as transfusion substitute. 4) hPSC-derived early innate immune cells and their functions. 5) Analysis of diseased hematopoiesis by using patient-specific iPSCs as the model.
Recently, we have successfully gained various grant support from government, such as “973 Project” and National Natural Science Foundation of China, etc. We cooperate with many other institutes and universities such as State Key Lab of Experimental Hematology (Tianjin), Institute of Basic Medical Sciences, Zhejiang University, and set several joint laboratories with companies to develop possibe clinical applications. With 16 staffs, including 2 senior engineers and 12 masters and doctors, we have published more than 26 papers in recent years.
We are interested in research on induction of hPSCs to functionally mature blood cells (erythrocytes, eosinophils, macrophages and mast cells, etc) and their possible applications. We are also interested in establishing high efficient methods to reprogram a small amount human peripheral / umbilical cord blood cells into hiPSCs and developing diseased models.We are exploring the method to induce mature blood cells in whole humanized system and uncovering mechanisms controlling early hematopoiesis through regulating genes and small molecules.

PI简介

马 峰 
        1983年本科毕业于南京医科大学,1992年硕士毕业于苏州大学医学院,2000年博士毕业于东京大学;1991-1992年,卫生部笹川奖学金研修生公派赴日(日本国信州大学)1996-1997年 卫生部笹川奖学金特别研究员公派赴日(日本国信州大学)1998-2000年 日本学术振兴会博士后特别研究员(东京大学)2000-2003年 日本国东京大学医科学研究所博士后研究员2003-2006年 日本国京都大学大学院医学研究科助理教授。2006-2010年 日本国东京大学医科学研究所助理教授2011-7022至尊国际至尊享受干细胞研究中心主任、中国医科学院7022至尊国际至尊享受特聘教授 ,2012-7022至尊国际至尊享受副所长(分管科研)。长期从事造血干细胞和人类ES/iPS细胞向造血细胞诱导分化的基础与临床应用研究。在人类ES/iPS细胞向红细胞以及自然免疫相关细胞等功能成熟血细胞的分化发育方面有创新成绩。
Tel:+86-28-61648510        Email:mafeng@hotmail.co.jp
Dr. Feng Ma, Stem Cell Biologist and Pediatric Hematologist, graduated from Nanjing Medical University in 1983, he worked as a pediatrician at Zhenjiang No.1 Hospital from 1983 to 1988. Since then, he had been working at the Children’s Hospital of Suzhou University and got his Master Degree in Medical Science in 1994. He first went to Japan in 1991 for one-year research on hematopoiesis and again to Japan in 1996 (Both by Sasakawa Medical Foundation, Department of Public Health of China). He gained his PhD Degree in Medical Science at the University of Tokyo in 2000. After then, he has been serving as a Postdoctoral Research Fellow,  and then an Assistant Professor, at the Institute of Medical Science, University of Tokyo and Kyoto University.
Dr. Ma’s recent main research is focusing on hESC / hiPSC-derived hematopoietic cells and their possible use in clinical applications. He is currently a Professor of the CAMS & PUMC and the Executive Director of the Institute of Blood Transfusion, CAMS.
苑宇哲
7022至尊国际至尊享受,副研究员。2008年获中国科学院动物研究所理学博士,于同年至7022至尊国际至尊享受工作。
研究内容:生物信息学的深度测序的数据分析及应用。
通过对血液循环中的DNA,血液中病原体,干细胞的风险因子,血液的干纸板等对象的监测,从而获得细胞转化的marker(相关于癌症发生),外源性病毒,内源性病毒,细菌感染,支原体感染,未知新发病毒体因子,从而为输血医学提供基础医学理论支持。
E-mail: yuzhe.yuan@gmail.com
Yuan, Yuzhe
2008.11, Ph. D. in science Institute of Zoology Chinese Academy of Science, China. 2008.11-present Research Associate Institute of blood transfusion Chinese Academy of Medical Sciences, China
Research Area
Bioinformatics Data analysis and application of deep sequencing
This research area focus on monitoring DNA and pathogens in blood circulation, risk factors in stem cells and dried cardboard of blood, in order to get marker of cell transformation (related to cancer), and information of exogenous virus, endogenous virus, bacterial infections, mycoplasma infection and unknown emerging virions. This research work will provide basic medical theory support to transfusion medicine.

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